Akbar, S., C. M. Chang, T. A. Gaidenko, and C. W. Price. 1997. Modulation protein RsbR regulates environmental signalling in the general stress pathway of Bacillus subtilis. Mol. Microbiol. 24:567-78.
Alting-Mees, M. A., and J. M. Short. 1989. pBluescript II: gene mapping vectors. Nucleic Acids Res. 17: 9494.
Altschul, S. F., T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller, and D. J. Lipman. 1997. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucl. Acid Res. 25:3389-3402.
Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
Archer, G. L., and M. J. Tenebaum. 1980. Antibiotic-resistant Staphylococcus epidermidis in patients undergoing cardiac surgery. Antimicrob. Agents Chemother. 17:269-272.
Arber, N., E. Pras, Y. Copperman, J. M. Schapiro, V. Meiner, I. S. Lossos, A. Militianu, D. Hassin, E. Pras, A. Shai, et al. 1994. Pacemaker endocarditis. Report of 44 cases and review of the literature. Medicine Baltimore. 73: 299-305.
Arnvig, K., B. Hove-Jensen, and R. L. Switzer. 1990. Purification and properties of phosphoribosyl-diphosphate synthase from Bacillus subtilis. Eur. J. Biochem. 192:195-200.
Baldassarri, L., W. A. Simpson, G. Donelli, and G. D. Christensen. 1993. Variable fixation of staphylococcal slime by different histochemical fixatives. Eur. J. Clin. Microbiol. Infect. Dis. 12:866-868.
Benson, A. K., and W. G. Haldenwang. 1992. Characterization of a regulatory network that controls sB expression in Bacillus subtilis. J. Bacteriol. 174:749-757.
Benson, A. K., and W. G. Haldenwang. 1993. The sB-dependent promotor of the Bacillus subtilis sigB operon is induced by heat shock. J. Bacteriol. 175:1929-1935.
Birnboim, H. C., and J. Doly. 1979. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucl. Acid. Res. 7:1513-1523.
Boyce, J. M. 1997. Epidemiology and prevention of nosocomial Infections. In: Crossley, K.B., and G. L. Archer (eds.) The Staphylococci in human disease. Churchill Livingstone New York, Edinburgh, London, Madrid, Melbourne, San Fransisco, Tokyo.
Boylan, S. A., A. Rutherford, S. M. Thomas, and C.W. Price. 1992. Activation of Bacillus subtillis transcription factor sB by a regulatory pathway responsive to stationary-phase signals. J. Bacteriol. 174:3695-3706.
Boylan, S. A., A. R. Redfield, M. S. Brody, and C.W. Price. 1993. Stress-induced activation of the sB transcription factor of Bacillus subtilis. J. Bacteriol. 175:7931-7937.
Chan, P. F., S. J. Foster, E. Ingham, and M. O. Clements. 1998. The Staphylococcus aureus alternative sigma factor sB controls the environmental stress response but not starvation survival or pathogenicity in a mouse abscess model. J. Bacteriol. 180:6082-6089.
Cohen, S. N., A. C. Y. Chang, and L. Hsu. 1972. Nonchromosomal antibiotic resistance in bacteria: Genetic transformation of Escherichia coli by R-factor DNA. Proc. Natl. Acad. Sci. 69:2110-2114.
Christensen, G. D., W. A. Simpson, A. L. Bisno, and E. H. Beachey. 1982. Adherence of slime producing Staphylococcus epidermidis to smooth surfaces. Infect. Immun. 37:318-326.
Christensen, G. D., W. A. Simpson, A. L. Bisno, and E. H. Beachey. 1983. Experimental foreign body infections in mice challenged with slime-producing Staphylococcus epidermidis. Infect. Immun. 40:407-410.
Christensen, G. D., W. A. Simpson, J. J. Younger, L. M. Baddour, F. F. Barrett, D. M. Melton, and E. H. Beachey. 1985. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for adherence of staphylococci to medical devices. J. Med. Microbiol. 22:996-1006.
Christensen, G. D., L. M. Baddor, and W. A. Simpson. 1987. Phenotypic variation of Staphylococcus epidermidis slime production in vitro and in vivo. Infect. Immun. 55:2870-2877.
Christensen, G. D., L. M. Baddour, B. M. Madison, J. T. Parisi, S. N. Abraham, D. L. Hasty, J. H. Lawrence, J. A. Joseph, and W. A. Simpson. 1990. Colonial morphology of staphylococci on memphis agar: phase variation of slime production, resistance to ß-lactam antibiotics, and virulence. J. Infect. Dis. 161:1153-1169.
Christensen, G. D., L. Baldassarri, and W.A. Simpson. 1994. Colonisation of medical devices by coagulase-negative staphylococci. Infection associated with indwelling medical divices. 2nd ed. 45-78.
Costerton, J. W., Z. Lewandowski, D. E. Caldwell, D. R. Korber, and H. Lappin-Scott. 1995. Microbial biofilms. Annu. Rev. Microbiol. 49:711-745.
Dagert, M., and S. D. Ehrlich. 1979. Prolonged incubation in calcium chloride improves the competence of Escherichia coli cells. Gene 6:23-28.
Deora, R., T. Tseng, and T. K. Misra. 1997. Alternative transcription factor sSB of Staphylococcus aureus: characterization and role in transcription of the global regulatory locus sar. J. Bacteriol. 179:6355-6359.
Dufour, A., and W. G. Haldenwang. 1994. Interactions between a Bacillus subtilis Anti- sB factor (RsbW) and its antagonist (RsbV). J. Bacteriol. 176:1813-1820.
Ebbole, D. J., and H. Zalkin. 1987. Cloning and characterization of a 12-gene cluster from Bacillus subtilis encoding nine enzymes for de novo purine nucleotide synthesis. J. Biol. Chem. 262:8274-8287.
Ebbole, D. J., and H. Zalkin. 1989a. Bacillus subtilis pur operon expression and regulation. J. Bacteriol. 171:2136-2141.
Ebbole, D. J., and H. Zalkin. 1989b. Interaction of a putative repressor protein with an extended control region of the Bacillus subtilis pur operon. J. Biol. Chem. 264:3553-3561.
Edmiston, C. E. Jr., D. D. Schmitt, and G. R. Seabrook. 1989. Coagulase-negative staphylococcal infections in vascular surgery: epidemiology and pathogenesis. Infect. Control. Hosp. Epidemiol. 10:111-117.
Eisenberg, E. S., M. Ambalu, G. Szylagi, V. Aning, and R. Soeiro 1987. Colonization of skin and development of peritonitis due to coagulase-negative staphylococci in patients undergoing peritoneal dialysis. J. Infect. Dis. 156: 478-482.
Emori, T. G., and R. P. Gaines. 1993. An overview of nosocomial infections, including the role of the microbiology laboratory. Clin. Microbiol. Rev. 6:428-442.
Farber, B. F., M. H. Kaplan, and A. G. Clogston. 1990. Staphylococcus epidermidis extracted slime inhibits the antimicrobial action of glycopeptide antibiotics. J. Infect. Dis. 161:37-40.
Fichtenbaum, C. J., W. C. Dunagan, and W.G. Powderly. 1995. Bacteremia in hospitalized patients infected with the human immunodeficiency virus: a case-control study of risk factors and outcome. J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. 8: 51-57.
Gardner, P., T. Leipzig, and P. Phillips. 1985. Infections of central nervous system shunts. Med. Clin. North. Am. 69: 297-314.
Gerke, C., A. Kraft, R. Süßmuth, O. Schweitzer, and F. Götz. 1998. Characterisation of the N-acetyl-glucosamintransferase activity involved in the biosynthesis of the Staphylococcus epidermidis polysaccharid intercellular adhesin. J. Biol. Chem 273:18586-18593.
Gutierrez, J. A., P. J. Crowley, D. P. Brown, J. D. Hillman, P. Youngman, and A. S. Bleiweis. 1996. Insertional mutagenesis and recovery of interrupted genes of Streptococcus mutans by using transposon Tn917: preliminary characterization of mutants. J. Bacteriol. 178:4166-4175.
Heilmann, C., O. Schweitzer, C. Gerke, N. Vanittanakom, D. Mack, and F. Götz. 1996. Molecular basis of intercellular adhesion in the biofilm-forming Staphylococcus epidermidis. Mol. Microbiol. 20:1083-1091.
Heilmann, C., M. Hussain, G. Peters, and F. Götz. 1997. Evidence for autolysin-mediated attachment of Staphylococcus epidermidis to a polystyrene surface. Mol. Microbiol. 24:1013-1024
Huebner, J., G. B. Pier, J. N. Maslow, E. Muller, H. Shiro, M. Parent, A.Kropec, R. D. Arbeit, and D. A. Goldmann. 1994. Endemic nosocomial transmission of Staphylococcus epidermidis bacteremia isolates in a neonatal intensive care unit over 10 years. J. Infect. Dis. 169:526-531.
Hussain, M., M. Herrmann, C. von Eiff, F. Perdreau-Remington, and G. Peters. 1997. A 140-kilodalton extracellular protein is essential for the accumulation of Staphylococcus epidermidis strains on surfaces. Infect. Immun. 65:519-524.
Inman, R. D., K. V. Gallegos, B. D. Brause, P. B. Redecha, and C. L. Christian. 1984. Clinical and microbial features of prosthetic joint infection. Am. J. Med. 77: 47-53.
Kang, C. M., M. S. Brody, S. Akbar, X. Yang, and C.W. Price. 1996. Homologous pairs of regulatory proteins control activity of Bacillus subtilis transcription Factor sB in response to environmental stress. J. Bacteriol. 178:3846-3853.
Karchmer, A. W., and A. L. Bisno. 1989. Infections of prosthetic heart valves and vascular grafts. P 129-159. In A. L. Bisno and F. A. Waldvogel (eds.): Infections associated with indwelling medical divices. American Society for Microbiology, Washington, DC.
Kernodle D. S., N. L. Barg, and A. B. Kaiser. 1988. Low-level colonisation of hospitalized patients with methicillin-resistant coagulase-negative staphylococci and emergence of the organisms during surgical antimicrobiol prophylaxis. Antimicrob. Agents Chemother. 32:202-208.
Kloos, W. E., and T. L. Bannerman. 1994. Update on clinical significance of coagulase- negative staphylococci. Clin. Microbiol. Rev. 7:117-140.
Kloos, W. 1997. Taxonomy and systematics of staphylococci indigenous to humans. In: Crossley, K.B., and G. L. Archer (eds.) The Staphylococci in human disease. Churchill Livingstone New York, Edinburgh, London, Madrid, Melbourne, San Fransisco, Tokyo.
Kotilainen, P., S. Huovinen, H. Jarvinen, H. Arvo, and P. Huovinen. 1995. Epidemiology of the colonization of inpatients and outpatients with ciprofloxacin-resistant coagulase-negative staphylococci. Clin. Infect. Dis. 21: 685-687.
Kullik, I., and P. Giachino. 1996. The alternative sigma factor sB in Staphylococcus aureus: regulation of the sigB operon in response to growth phase and heat shock. Arch. Microbiol. 167:151-159.
Kullik, I., P. Giachino, and T. Fuchs. 1998. Deletion of the alternative sigma factor sB in Staphylococcus aureus reveals ist function as a global regulator of virulence genes. J. Bacteriol. 180:4814-4820.
Levy, M. F., D. D. Schmitt, C. E. Edminston, D. F. Bandyk, C. J. Krepel, G. R. Seabrook, and J. B. Towne. 1990. Sequential analysis of staphylococcal colonization of body surfaces of patients undergoing vascular surgery. J. Clin. Microbiol. 28:664-669.
Ludwicka, A., B. Jansen, T. Waldström, and G. Pulverer. 1984. Attachment of staphylococci to various synthetic polymers. Zbl. Bakt. Hyg., I Abt. Orig A 258:479-489.
Mack, D., N. Siemssen, and R. Laufs. 1992. Parallel induction by glucose of adhesion and a polysaccharide antigen specific for plastic-adherent Staphylococcus epidermidis: evidence for functional relation to intercellular adherence. Infect. Immun. 60:2048-2057.
Mack, D. 1994a. Genetische und immunchemische Untersuchungen zur Entstehung von adhärenten Biofilmen von Staphylococcus epidermidis auf Kunststoffoberflächen. Habilitationsschrift. Hamburg, 1994.
Mack, D., M. Nedelmann, A. Krokotsch, A. Schwarzkopf, J. Heesemann, and R. Laufs. 1994b. Characterization of transposon mutants of biofilm-producing Staphylococcus epidermidis impaired in the accumulative phase of biofilm-production: genetic identification of a hexosamine containing polysaccharide intercellular adhesin. Infect. Immun. 62:3244-3253.
Mack, D., N. Siemssen, and R. Laufs. 1994c. Identification of a cell cluster associated antigen specific for plastic-adherent Staphylococcus epidermidis which is functional related to intercellular adhesion. Zbl. Bakt. Suppl. 26:411-413.
Mack, D., M. Haeder, N. Siemssen, and R. Laufs. 1996a. Association of biofilm production of coagulase-negative staphylococci with expression of a specific polysaccharide intercellular adhesin. J. Infect. Dis. 174:881-884.
Mack, D., W. Fischer, A. Krokotsch, K. Leopold, R. Hartmann, H. Egge, and R. Laufs. 1996b. The intercellular adhesin involved in biofilm accumulation of Staphylococcus epidermidis is a linear ß-1,6-linked glucosaminoglycan: purification and structural analysis. J. Bacteriol. 178:175-183.
Mack, D. 1999a. Molecular mechanisms of Staphylococcus epidermidis biofilm formation. J. Hosp. Infect. (in press).
Mack, D., J. Riedewald, H. Rohde, T. Magnus, H. H. Feucht, H.-A. Elsner, R. Laufs, and M. E. Rupp. 1999b. Essential functional role of the polysaccharide intercellular adhesin of Staphylococcus epidermidis in hemagglutination. Infect. Immun. 67:1004-1008.
Marples, R. R. 1992. Epidemilogic typing of coagulase-negative staphylococci. Curr. Opin. Infect. Dis. 5:530
Nedelmann, M., A. Sabottke, R. Laufs, and D. Mack. 1998. Generalized transduction for genetic linkage analysis and transfer of transposon insertions in different Staphylococcus epidermidis strains. Zentbl. Bakteriol. 287:85-92.
Nilsson, M., L. Frykberg, J. I. Flock, L. Pei, M. Lindberg, and B. Guss. 1998. A fibrinogen-binding protein of Staphylococcus epidermidis. Infect. Immun. 66:2666-2673.
Parisi, J. T. 1985. Coagulase-negative staphylococci and the epidemiological typing of Staphylococcus epidermidis. Microbiol. Rev. 49:126-139.
Pascual, A., A. Fleer, N. A. C. Westerdaal, and J. Verhoef. 1986. Modulation of adherence of coagulase-negative staphylococci to teflon catheters in vitro. Eur. J. Clin. Microbiol. 5:518-522.
Peters, G., R. Locci, and G. Pulverer. 1981. Microbial colonization of prosthetic devices: II. scanning electron microscopy of natural infected intravenous catheters. Zbl. Bakt. Hyg., I Abt. Orig B 173:293-299.
Pfaller, M. A., and L. A. Herwaldt. 1988. Laboratory, clinical and epidemilogical aspects of coagulase-negative staphylococci. Clin. Microbiol. Rev. 1:281-299.
Powers, K. A., M. S. Terpenning, R. A. Voice, and C. A. Kauffman. 1990. Prosthetic joint infections in the elderly. Am. J. Med. 88(5N): 9N-13N.
Raad, I., S. Davis, A. Khan, J. Tarrand, L. Elting, and G. P. Bodey. 1992. Impact of central venous catheter removal on the recurrence of catheter-related coagulase-negative staphylococcal bacteremia. Infect. Control. Hosp. Epidemiol. 13: 215-221.
Rupp, M. E., and G. L. Archer. 1992. Hemagglutination and adherence to plastic by Staphylococcus epidermidis. Infect. Immun. 60:4322-4327.
Rupp, M. E., and G. L. Archer. 1994. Coagulase-negative staphylococci: pathogens associated with with medical progress. Clin. Infect. Dis. 19:231.
Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. 74:5463-5467.
Saxild, H. H., and P. Nygaard. 1991. Regulation of levels of purine biosynthetic enzymes in Bacillus subtilis: effects of changing purine nucleotide pools. J. Gen. Microbiol. 137:2387-2394.
Schleifer, K. H. 1986. Micrococcaceae. p. 1003. In Sneath (ed.): Bergey´s manual of systematic bacteriology Vol. 2. Williams and Wilkins, Baltimore.
Schuhmacher-Perdrea u, F., C. Heilmann, G. Peters, F. Götz, and F. Pulverer. Comparative analysis of a biofilm-forming Staphylococcus epidermidis strain and its adhesion-positive, accumulation-negative mutant M7. FEMS Microbiol. Lett. 117:71-78.
Shaw, J. H., and D. B. Clewell. 1985. Complete nucleotide sequence of macrolide-lincosamide-streptogramin B-resistance transposon Tn917 in Streptococcus faecalis. J. Bacteriol. 164:782-796.
Shin, B. S., A. Stein, and H. Zalkin. 1997. Interaction of Bacillus subtilis purine repressor with DNA. J. Bacteriol. 1997: 7394-7402.
Short, J. M., J. M. Fernandez, J. A. Sorga, and W. D. Huse. 1988. Lambda ZAP: a bacteriophage lambda expression vector with in vivo excision properties. Nucleic Acids Res. 16: 7583-7600.
Timmermann, C. P., A. Fleer, J. M. Besnier, L. de Graaf, F. Cremers, and J. Verhoef. 1991. Characterisation of a proteinaceous adhesin of Staphylococcus epidermidis which mediates attachment to polystyrene. Infect. Immun. 59:4187-4197.
Udo, E. E., and W. B. Grubb. 1990a. A new class of conjugative plasmid in Staphylococcus aureus. J. Med. Microbiol. 31:207-212.
Udo, E. E., and W. B. Grubb. 1990b. Conjugal transfer of plasmid pWBG637 from Staphylococcus aureus to Staphylococcus epidermidis and Streptococcus faecalis. FEMS Microbiol. Lett. 72:183-188.
Völcker U. S., Engelmann, B. Maul, S. Riethdorf, A. Völcker, R. Schmid, H. Mach, and M. Hecker. 1994. Charakterisation and analysis of the induction of general stress proteins of Bacillus subtilis. Microbiology 140:741-752.
Voelcker, U., A. Voelcker, B. Maul, M. Hecker, A. Dufour, and W. G. Haldenwang. 1995. Separate mechanisms activate sB of Bacillus subtilis in response to environmental and metabolic stresses. J. Bacteriol. 177:3771-3780.
Voelcker, U., A. Voelcker, and W. G. Haldenwang. 1996. Reactivation of the Bacillus subtilis anti-sigma B antagonist, RsbV, by stress- or starvation-induced phosphatase activities. J. Bacteriol. 178:5456-63.
Vogelstein, B., and D. Gillespie. 1979. Preparative and analytical purification of DNA from agarose. Proc. Natl. Acad. Sci. USA 76:615-619.
Waldvogel, F. A. 1994. Staphylococcus aureus (including toxic shock syndrome). In: Mandell, G.L., J. E. Bennett, and R. Dolin: Mandell, Douglas and Bennett´s principles and practice of infectious diseases. Churchill Livingstone, New York, Ediburgh, London, Madrid, Melbourne, Milan, Tokyo.
Weiß, B., A. Jacquemin-Sablon, T. R. Live, G. C. Fareed, and C. C. Richardson. 1968. Enzymatic breakage and joining of deoxyribonucleic acid. J. Biol. Chem. 243: 4543-4555.
Weng, M., P. L. Nagy, and H. Zalkin. 1995. Identification of the Bacillus subtilis pur operon repressor. Proc. Natl. Acad. Sci. USA 92:7455-7459.
West, T. E., J. J. Walshe, C. P. Krol, and D. Amsterdam. 1986. Staphylococal peritonitis in patients on continous peritoneal dialysis. J. Clin. Microbiol. 23:809-812.
Wu, S., H. De Lencastre, and A. Tomasz. 1996. Sigma-B, a putative operon encoding alternativ Sigma factor of Staphylococcus aureus RNA Polymerase: Molecular cloning and DNA sequencing. J. Bacteriol. 178:6036-6042.
Youngman, P. J. 1993. Transposons and their application, p. 585-596. In A. L. Sonenshein, J. A. Hoch, and R. Losick (eds.): Bacillus subtilis and other Gram-positive bacteria. American society for Microbiology, Washington, D. C.
Yu, P. K. W., and Washington J. A. 1985. Identification af aerobic and faculatively anaerobic bacteria. In Washington J. A. (ed): Laboratory Procedures in Clinical Microbiology. 2nd ed. New York: Springer-Verlag: 31-250.
Ziebuhr, W., C. Heilmann, F. Götz, P. Meyer, K. Wilms, E. Straube and J. Hacker. 1997. Detection of the intercellular adhesion gene cluster (ica) and phase variation in Staphylococcus epidermidis blood culture strains and mucosal isolates. Infect. Immun. 65:890-986.