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Dissertation zugänglich unter
URN: urn:nbn:de:gbv:18-50888
URL: http://ediss.sub.uni-hamburg.de/volltexte/2011/5088/


Estrogen receptor gene (ESR1) amplification occurs rarely in ovarian cancers

Östrogen-Rezeptor alpha (ESR1) Gen-Amplifekation ist selten bei malignen Ovarialtumoren

Issa, Rana

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 Dokument 1.pdf (714 KB) 


Basisklassifikation: 44.47
Institut: Medizin
DDC-Sachgruppe: Medizin, Gesundheit
Dokumentart: Dissertation
Hauptberichter: Sauter, Guido (Prof. Dr.)
Sprache: Englisch
Tag der mündlichen Prüfung: 24.02.2011
Erstellungsjahr: 2010
Publikationsdatum: 29.03.2011
Kurzfassung auf Englisch:
Amplification of the gene encoding estrogen receptor alpha occurs in about 20%
of breast cancers and is an important mechanism for estrogen receptor
overexpression in this tumor type. In ovarian cancer, overexpression of estrogen
receptor protein has been described in more than two thirds of cases. To study a
potential role of estrogen receptor alpha gene amplification for estrogen receptor
overexpression in ovarian cancer, a tumor tissue microarray containing 428
ovarian caners was analyzed by fluorescence in-situ hybridization for estrogen
receptor alpha gene amplification and immunohistochemistry for estrogen
receptors expression. The estrogen receptor alpha gene status was successfully
determined in 243/428 arrayed cancers. Estrogen receptor gene amplification
was found in 5/243 (2%) of tumors. Amplification levels were usually low with 4-8
estrogen receptor alpha gene copies. However, one case had a high level
amplification with more than 30 estrogen receptor alpha gene copies. All 5
amplified tumors were estrogen receptors positive with 3/5 tumors showing
highest (Allred score 7-8) estrogen receptor levels. The data demonstrate that
estrogen receptor alpha amplification occurs only rarely in ovarian cancer.

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