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Dissertation zugänglich unter
URN: urn:nbn:de:gbv:18-52169
URL: http://ediss.sub.uni-hamburg.de/volltexte/2011/5216/


High Resolution Multislice Computed Tomography in the early phase after Stem Cell Transplantation

Hochauflösende Mehrschicht Computertomographie in der frühen Phase nach Stammzelltransplantation

Littau, Odin

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 Dokument 1.pdf (7.049 KB) 


SWD-Schlagwörter: Computertomographie , Transplantation , Periphere Stammzellentransplantation
Basisklassifikation: 44.64
Institut: Medizin
DDC-Sachgruppe: Medizin, Gesundheit
Dokumentart: Dissertation
Hauptberichter: Weber, Christoph (Prof. Dr.)
Sprache: Englisch
Tag der mündlichen Prüfung: 30.05.2011
Erstellungsjahr: 2010
Publikationsdatum: 20.07.2011
Kurzfassung auf Englisch: Purpose: To evaluate the role of high resolution multislice computed tomography (HRCT) in the detection and monitoring of pulmonary infections after stem cell transplantation.
Materials and Methods: Over a 5-year period, 113 patients (52f/61m, mean age 46 years, range, 19-77) with fever of unknown origin after stem cell transplantation underwent examination by a multi-detector row HRCT for evaluation of possible pneumonia in a prospective study. A baseline HRCT was performed in 19/113 of these patients before stem cell transplantation due to a high risk profile, and 61/113 patients underwent follow-up HRCT within 60 days after stem cell transplantation. The standard for comparing the diagnosis of pneumonia with the radiological findings in a total of 232 HRCT was based on combination of bronchoscopy, biochemistry and microbiological data.
Results: HRCT detected pulmonary opacities in 73/113 patients after stem cell transplantation (19/73 fungal pneumonia, 17/73 bacterial pneumonia, 4/73 viral pneumonia, 33/73 non specific). The sensitivity, specificity and diagnostic accuracy of HRCT for pneumonia was 86%, 75% and 80% respectively. Diagnostic accuracy increased to 83% when follow-up HRCT was performed.
Conclusion: HRCT was useful for detection and monitoring of pulmonary infections after stem cell transplantation.

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