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Dissertation zugänglich unter
URN: urn:nbn:de:gbv:18-57047
URL: http://ediss.sub.uni-hamburg.de/volltexte/2012/5704/


Lung function in asbestos-exposed workers, a systematic review and meta-analysis

Lungenfunktionsveränderungen asbestexponierter Arbeiter, eine systematische Übersicht und Metaanalyse

Wilken, Dennis ; Velasco Garrido, Marcial ; Manuwald, Ulf ; Baur, Xaver

Originalveröffentlichung: (2012) Journal of Occupational Medicine and Toxicology 2011, 6:21
pdf-Format:
 Dokument 1.pdf (2.342 KB) 


Freie Schlagwörter (Englisch): Asbestos , lung function , chest X-ray , computed tomography , meta-analysis
Basisklassifikation: 44.12
Institut: Medizin
DDC-Sachgruppe: Medizin, Gesundheit
Dokumentart: Dissertation
Hauptberichter: Baur, Xaver (Prof. Dr.)
Sprache: Englisch
Tag der mündlichen Prüfung: 31.05.2012
Erstellungsjahr: 2012
Publikationsdatum: 18.07.2012
Kurzfassung auf Deutsch: Background: A continuing controversy exists about whether, asbestos exposure is associated with significant lung function impairments when major radiological abnormalities are lacking. We conducted a systematic review and meta-analysis in order to assess whether asbestos exposure is related to impairment of lung function parameters independently of the radiological findings.

Methods: MEDLINE was searched from its inception up to April 2010. We included studies that assessed lung function parameters in asbestos exposed workers and stratified subjects according to radiological findings. Estimates of VC, FEV1 and FEV1/VC with their dispersion measures were extracted and pooled.

Results: Our meta-analysis with data from 9,921 workers exposed to asbestos demonstrates a statistically significant reduction in VC, FEV1 and FEV1/VC, even in those workers without radiological changes. Less severe lung function impairments are detected if the diagnoses are based on (high resolution) computed tomography rather than the
less sensitive X-ray images. The degree of lung function impairment was partly related to the proportion of smokers included in the studies.

Conclusions: Asbestos exposure is related to restrictive and obstructive lung function impairment. Even in the absence of radiological evidence of parenchymal or pleural diseases there is a trend for functional impairment.

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