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Dissertation zugänglich unter
URN: urn:nbn:de:gbv:18-59705
URL: http://ediss.sub.uni-hamburg.de/volltexte/2012/5970/


Evaluation der primären Implantatstabilität nach experimenteller Sinusbodenelevation mit autologen mesenchymalen Stammzellen

Riecke, Björn

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 Dokument 1.pdf (1.059 KB) 


Freie Schlagwörter (Deutsch): Stammzellen , Sinusbodenaugmentation , primäre Implantatstabilität
Freie Schlagwörter (Englisch): stem cells , sinus floor augmentation , primary implant stability
Basisklassifikation: 44.96
Institut: Medizin
DDC-Sachgruppe: Medizin, Gesundheit
Dokumentart: Dissertation
Hauptberichter: Amling, Michael (Prof. Dr.)
Sprache: Deutsch
Tag der mündlichen Prüfung: 22.08.2012
Erstellungsjahr: 2012
Publikationsdatum: 06.12.2012
Kurzfassung auf Englisch: OBJECTIVES
To mechanically evaluate the effect of transplantation of precultured preosteoblasts derived from autogenic adult stem cells (aMSC) for experimental sinus floor augmentation on primary dental implant
stability in comparison to conventional augmentation procedures in rabbits.
MATERIAL AND METHODS
After experimental sinus floor augmentation with a synthetic bone substitute, autogenous bone transplantation or osteoblast precursor cells the primary stability of implants inserted in the edentulous
part of the upper jaw of New Zealand White Rabbits was examined. Mechanical evaluation was performed by determination of insertion torque values (Osseocare™), percussion testing (Periotest™),
resonance frequency analysis (Osstell™ and scanning laser Doppler vibrometer) and measurement of extraction forces.
RESULTS
Evaluation of mechanical properties with percussion testing and resonance frequency analysis with Osstell™ revealed slightly higher primary stability of the stem cell group whereas the scanning laser
Doppler vibrometer and measurement of pull-out forces showed no significant difference to the bone substitute group. Transplantation of autogenous bone graft resulted in highest primary implant
stability.
CONCLUSIONS
The three examination modalities proved suitable for the determination of primary implant stability. The experimental maxillary sinus floor augmentation with precultured osteoblast precursor cells from
autogenic stems cells clearly enhanced primary stability of implants compared to the unaugmented sinus and lead to comparable primary mechanical properties to bone substitutes in rabbits. In comparison to the autogenous bone graft stability enhancement by stem cell transplantation declined.

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