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Dissertation zugänglich unter
URN: urn:nbn:de:gbv:18-73325
URL: http://ediss.sub.uni-hamburg.de/volltexte/2015/7332/


Polymorphismen im NFKBIA Gen und akute Abstoßungsreaktionen nach Lebertransplantation

Polymorphisms in NFKBIA gene and acute rejections in liver transplant recipients

Kramer, Kathrin Stefanie

Originalveröffentlichung: (2015) Tissue Antigens 2014 Oct;84(4):370-7
pdf-Format:
 Dokument 1.pdf (6.817 KB) 


Freie Schlagwörter (Deutsch): Polymorphismus , Lebertransplantation , akute Abstoßung , NFKBIA , NFkappaB
Freie Schlagwörter (Englisch): polymorphism , liver transplant , acute rejection , NFKBIA , NFkappaB
Basisklassifikation: 44.65
Institut: Medizin
DDC-Sachgruppe: Medizin, Gesundheit
Dokumentart: Dissertation
Hauptberichter: Sterneck, Martina (Prof. Dr.)
Sprache: Deutsch
Tag der mündlichen Prüfung: 08.05.2015
Erstellungsjahr: 2015
Publikationsdatum: 02.06.2015
Kurzfassung auf Englisch: The nuclear factor of kappa light polypeptide gene enhancer B-cells inhibitor-alpha (NFKBIA) gene encodes a member of the nuclear factor-kappa-B inhibitor family. Polymorphisms in this gene might be associated with a susceptibility to acute rejection episodes following liver transplantation, as they may cause an increased activation level of the proinflammatory transcription factor nuclear factor of kappa light polypeptide gene enhancer in B-cells (NFκB). The aim of this study was to evaluate whether the NFKBIA polymorphisms −297 C/T (rs2233409), −826 C/T (rs2233406) and 126 G/A (rs696) affect the incidence of acute liver graft rejection. A total of 199 liver transplant recipients was analyzed, 100 without (NAR) and 99 with early acute rejection(AR). Thirty-two individuals with multiple acute rejections (MAR) were analyzed as a subgroup of AR. Polymerase chain reaction-allele specific restriction enzyme analysis (PCR-ASRA) and allele-specific hybridization with fluorescence resonance energy transfer (FRET) were used for genotyping. We identified the genotype NFKBIA 126AA (P=0.002) as well as the haplotype NFKBIA–126A–297T–826T (P=0.002) as a potential risk factor for the occurrence of recurrent acute rejections. Furthermore, we assessed an association between the 126 A allele and susceptibility to recurrent acute rejections (P=0.027). Our data suggest that the NFKBIA 126 G/A polymorphism might be potentially helpful to identify liver transplant recipients with an increased susceptibility to develop recurrent acute rejections.

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