DC ElementWertSprache
dc.contributor.advisorSchwabe, Lars-
dc.contributor.authorGrob, Anna-Maria-
dc.date.accessioned2024-02-01T12:05:16Z-
dc.date.available2024-02-01T12:05:16Z-
dc.date.issued2023-
dc.identifier.urihttps://ediss.sub.uni-hamburg.de/handle/ediss/10708-
dc.description.abstractUpdating memory is essential for maintaining an accurate model of the world. Yet, our understanding of how we integrate new information into existing memory has remained limited. Therefore, this work aims to delineate the factors that shape mnemonic integration. Building upon prior research emphasizing the anterior hippocampus's role in mnemonic integration and the impact of stress on hippocampal function, Study 1 leveraged fMRI to explore how acute stress affects mnemonic integration. Although stress boosted recognition, it disrupted a representational change in the anterior hippocampus, likely by decreasing hippocampal activity during insight. Inspired by the anterior hippocampus’s role in mnemonic integration and imagination, Study 2 utilized fMRI to investigate the behavioral and neural consequences of imagination-based insight. While improving overall memory, imagination resulted in lower immediate insight and abolished a representational change in the anterior hippocampus, possibly due to heightened hippocampal activity during imagination. To explore the role of the angular gyrus in mnemonic integration, given its implications in memory and imagination, we combined inhibitory continuous theta burst stimulation (cTBS) at the angular gyrus with electroencephalography (EEG) in Study 3. Angular gyrus inhibition reduced the memory boost for integrated narratives and eliminated representational changes for linked events in the theta band. These findings converge in a comprehensive model, positing the angular gyrus as a buffer and proposing an inverted U-shaped relationship between hippocampal activity and mnemonic reconfiguration when integrating previously separate events. Altogether, these insights enhance our comprehension of mnemonic integration and may aid in developing a better understanding of the etiology of conditions such as posttraumatic stress disorder (PTSD).de
dc.language.isoende_DE
dc.publisherStaats- und Universitätsbibliothek Hamburg Carl von Ossietzkyde
dc.relation.hasparthttps://doi.org/10.1016/j.neuroimage.2022.119804de_DE
dc.relation.hasparthttps://doi.org/10.1093/cercor/bhad048de_DE
dc.relation.hasparthttps://doi.org/10.7554/eLife.91033.1de_DE
dc.rightshttp://purl.org/coar/access_right/c_abf2de_DE
dc.subjectMemory integrationen
dc.subjectAngular gyrusen
dc.subjectAnterior hippocampusen
dc.subjectInsighten
dc.subjectPTSDen
dc.subjectStriatumen
dc.subject.ddc150: Psychologiede_DE
dc.titleAn Insightful Trio: Stress, Imagination and the Angular Gyrus Shape Mnemonic Integrationde
dc.title.alternativeEin aufschlussreiches Trio: Stress, Imagination und der Gyrus Angularis formen die Gedächtnisintegrationde
dc.typedoctoralThesisen
dcterms.dateAccepted2024-01-26-
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/de_DE
dc.rights.rshttp://rightsstatements.org/vocab/InC/1.0/-
dc.subject.bcl77.31: Kognitionde_DE
dc.subject.gndKognitionde_DE
dc.subject.gndEpisodisches Gedächtnisde_DE
dc.subject.gndAssoziatives Gedächtnisde_DE
dc.subject.gndAngularde_DE
dc.subject.gndHippocampusde_DE
dc.subject.gndTranskranielle magnetische Stimulationde_DE
dc.subject.gndElektroencephalographiede_DE
dc.subject.gndFunktionelle Kernspintomografiede_DE
dc.subject.gndStressde_DE
dc.subject.gndImaginationde_DE
dc.type.casraiDissertation-
dc.type.dinidoctoralThesis-
dc.type.driverdoctoralThesis-
dc.type.statusinfo:eu-repo/semantics/publishedVersionde_DE
dc.type.thesisdoctoralThesisde_DE
tuhh.type.opusDissertation-
thesis.grantor.departmentPsychologiede_DE
thesis.grantor.placeHamburg-
thesis.grantor.universityOrInstitutionUniversität Hamburgde_DE
dcterms.DCMITypeText-
dc.identifier.urnurn:nbn:de:gbv:18-ediss-115161-
item.advisorGNDSchwabe, Lars-
item.grantfulltextopen-
item.languageiso639-1other-
item.fulltextWith Fulltext-
item.creatorOrcidGrob, Anna-Maria-
item.creatorGNDGrob, Anna-Maria-
Enthalten in den Sammlungen:Elektronische Dissertationen und Habilitationen
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