DC ElementWertSprache
dc.contributor.advisorSchlüter, Hartmut-
dc.contributor.authorHaghiri Limoudehi, Rosa-
dc.date.accessioned2024-03-07T14:14:52Z-
dc.date.available2024-03-07T14:14:52Z-
dc.date.issued2023-
dc.identifier.urihttps://ediss.sub.uni-hamburg.de/handle/ediss/10774-
dc.description.abstractDiabetes mellitus (DM) is a metabolic disorder characterized by insufficient regulation of glucose levels in the bloodstream. The prevalence of diabetes is increasing globally and is associated with various complications, including an increased risk of cardiovascular diseases (CVDs). Platelet dysfunction is a key factor in the development of these complications. Platelets release extracellular vesicles (EVs), which play a role in inflammation, thrombosis, and the transmission of biological information. In diabetes, platelet-EVs can promote endothelial dysfunction and contribute to the progression of diabetic complications. By extracting platelet proteins and studying their proteome, as well as the proteome of plasma-derived EVs, valuable insights can be gained into the molecular mechanisms that underlie platelet hyperactivity, thrombus formation, and complications related to diabetes.de
dc.language.isoende_DE
dc.publisherStaats- und Universitätsbibliothek Hamburg Carl von Ossietzkyde
dc.rightshttp://purl.org/coar/access_right/c_abf2de_DE
dc.subjectProteomicsen
dc.subjectExtracellular vesiclesen
dc.subjectSP3en
dc.subjectMass spectrometryen
dc.subjectPlateletsen
dc.subjectCardiovascular diseasesen
dc.subject.ddc540: Chemiede_DE
dc.titleDifferential Quantitative Proteomics of Platelets and Extracellular Vesicles in Patients with Diabetes Mellitusen
dc.typedoctoralThesisen
dcterms.dateAccepted2024-03-01-
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/de_DE
dc.rights.rshttp://rightsstatements.org/vocab/InC/1.0/-
dc.subject.bcl35.00: Chemie: Allgemeinesde_DE
dc.subject.gndDiabetes mellitusde_DE
dc.type.casraiDissertation-
dc.type.dinidoctoralThesis-
dc.type.driverdoctoralThesis-
dc.type.statusinfo:eu-repo/semantics/publishedVersionde_DE
dc.type.thesisdoctoralThesisde_DE
tuhh.type.opusDissertation-
thesis.grantor.departmentChemiede_DE
thesis.grantor.placeHamburg-
thesis.grantor.universityOrInstitutionUniversität Hamburgde_DE
dcterms.DCMITypeText-
dc.identifier.urnurn:nbn:de:gbv:18-ediss-116058-
item.advisorGNDSchlüter, Hartmut-
item.grantfulltextopen-
item.languageiso639-1other-
item.fulltextWith Fulltext-
item.creatorOrcidHaghiri Limoudehi, Rosa-
item.creatorGNDHaghiri Limoudehi, Rosa-
Enthalten in den Sammlungen:Elektronische Dissertationen und Habilitationen
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