Titel: | The role of conventional dendritic cell subsets in T-cell activation in Ebola virus infection | Sprache: | Englisch | Autor*in: | Niemetz, Linda Rita | Schlagwörter: | Ebola virus; Dendritic cells; T-cell activation; Cross-presentation; Virus Immunology | Erscheinungsdatum: | 2024 | Tag der mündlichen Prüfung: | 2024-06-28 | Zusammenfassung: | Severe Ebola virus disease (EVD) is characterized by excess, dysregulated T cell activation and high levels of inflammation. In conflict with these clinical observations, in vitro studies described that Ebola virus (EBOV) infection of monocyte-derived dendritic cells (moDCs), results in suppression of T cell activation due to inhibition of DC activation. However, it is unknown how other DC subsets distinct from moDCs respond to EBOV infection. Therefore, we assessed the response of FMS-like tyrosine kinase 3 (Flt3)-dependent, conventional mouse DCs (cDCs) to EBOV infection, and studied their CD8 T-cell activation capacity in a DC-T cell co-culture system utilizing a recombinant EBOV expressing the model antigen ovalbumin. Our data indicate that EBOV infection of mouse cDCs, results in activation rather than inhibition, promotes antigen cross-presentation and thus, leads to high levels of CD8 T cell activation. With that, we propose a mechanistic explanation for the excess T cell activation observed in severe human EVD. |
URL: | https://ediss.sub.uni-hamburg.de/handle/ediss/11001 | URN: | urn:nbn:de:gbv:18-ediss-119053 | Dokumenttyp: | Dissertation | Betreuer*in: | Munoz-Fontela, César Oestereich, Lisa Rodriguez-Burgos, Estefania |
Enthalten in den Sammlungen: | Elektronische Dissertationen und Habilitationen |
Dateien zu dieser Ressource:
Datei | Beschreibung | Prüfsumme | Größe | Format | |
---|---|---|---|---|---|
Dissertation Linda Niemetz_final Stabi - online version.pdf | Dissertation_Linda Niemetz_ final | 4bf6def087ffba60137c216a9c29f8ef | 6.15 MB | Adobe PDF | Öffnen/Anzeigen |
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