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Dissertation zugänglich unter
URN: urn:nbn:de:gbv:18-96318
URL: http://ediss.sub.uni-hamburg.de/volltexte/2019/9631/


Functionalized Prodrugs of a bacterial RNAP-Inhibitor & Bio-reversibly masked purinergic 2nd Messenger derivatives associated with Ca2+ Signaling

Funktionalisierte Prodrugs eines Inhibitors der bakteriellen RNAP & Bio-reversibel maskierte purinerge sekundäre Botenstoffderivate

Ruthenbeck, Alexandra

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 Dokument 1.pdf (9.747 KB) 


Freie Schlagwörter (Deutsch): Nucleotide , Antibiotikum , Prodrugs
Freie Schlagwörter (Englisch): nucleotide , antibiotics , prodrug
Basisklassifikation: 35.50
Institut: Chemie
DDC-Sachgruppe: Chemie
Dokumentart: Dissertation
Hauptberichter: Meier, Chris (Prof. Dr.)
Sprache: Deutsch
Tag der mündlichen Prüfung: 11.01.2019
Erstellungsjahr: 2018
Publikationsdatum: 21.03.2019
Kurzfassung auf Englisch: This thesis aimed at conjugating two aryl-ureidothiophene carboxylic acids with moieties that provide the capacity to coordinate FeIII. In addition, spacer groups were introduced to facilitate enzymatic prodrug activation. The FeIII-coordination of the siderophore-type prodrugs was evaluated in a competitive assay to yield relative affinities. The antibiotic activity of all prodrugs, i.e. lipophilic, cationic and functionalized, was determined.
In a further aspect, this thesis aimed at developing synthetic access towards AB-masked derivatives of cNMPs, (d)ADPR and NAADP. Introduction of the AB-mask in a (site-) specific way and thus in total synthesis approaches was preferably considered. Based on the complexity of the dinucleotides in molecular structure, convergent synthesis routes with a final coupling step were designed.

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