Titel: Comparing Stem Cell Characteristics of Paired Stem cells from Apical Papillae and Dental Pulps before and after Cryopreservation
Sprache: Englisch
Autor*in: Nada, Ola Abdelmoniem Azab Abdelaziz
Schlagwörter: SCAP; DPSCs; Cryopreservation
GND-Schlagwörter: StammzelleGND
Induzierte pluripotente StammzelleGND
KnochenregenerationGND
Erscheinungsdatum: 2021
Tag der mündlichen Prüfung: 2022-05-17
Zusammenfassung: 
The purpose of the study is to compare stem cell characteristics between cells from the apical papilla and the dental pulp throughout 12 passages with and without being subjected to cryopreservation. The hypothesis is that with passage progress, cells are more likely to undergo senescence and lose their stem cell characteristics. The study also hypothesizes that cells from the apical papilla might display superior potency in stem cell characteristics owing to their origin from developing and therefore more immature and younger tissues.

The results of the thesis concluded that apical papilla cells were found to portray more potent osteogenic differentiation and spheroid formation abilities when compared to dental pulp cells. Both cell types displayed similar growth, colony forming efficiency, viability, population doublings, and adipogenic differentiation. Finally, apical papilla and dental pulp cells can be cryopreserved for at least one year without substantial characteristic changes.
URL: https://ediss.sub.uni-hamburg.de/handle/ediss/9674
URN: urn:nbn:de:gbv:18-ediss-101396
Dokumenttyp: Dissertation
Betreuer*in: Smeets, Ralf
Enthalten in den Sammlungen:Elektronische Dissertationen und Habilitationen

Dateien zu dieser Ressource:
Datei Beschreibung Prüfsumme GrößeFormat  
Submission_Thesis_OlaNada.pdfOla Nada_SubmittedThesis02705224a64f574fbb449ed22d4d90ae5.78 MBAdobe PDFÖffnen/Anzeigen
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